Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596338 | 0.88 | FGFR4 (0.51) | EGFRPTK2MAPK3NUAK2NUAK1 | |
| SCHEMBL30379997 | 0.85 | SLC2A1 (0.49) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL21596373 | 0.84 | MAPK3 (0.47) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL21600829 | 0.83 | MAPK3 (0.46) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL30380211 | 0.83 | PTK2 (0.51) | EGFRPTK2NUAK2NUAK1IGF1R | |
| SCHEMBL28531524 | 0.83 | PTK2 (0.51) | EGFRPTK2NUAK2NUAK1IGF1R | |
| SCHEMBL28539737 | 0.83 | ALK (0.52) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL30379995 | 0.83 | ALK (0.52) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL21596348 | 0.83 | ALK (0.54) | EGFRPTK2MAPK3IGF1RAURKA | |
| SCHEMBL21596306 | 0.83 | ALK (0.51) | EGFRPTK2MAPK3IGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |