Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.61 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | TXK | P42681 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21601019 | 0.89 | JAK3 (0.66) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21600955 | 0.88 | JAK3 (0.47) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21601013 | 0.87 | JAK3 (0.63) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21601008 | 0.86 | JAK3 (0.71) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21601021 | 0.86 | MAP3K7 (0.59) | JAK3EGFRFLT3MAP3K7MAPK3 | |
| SCHEMBL21601022 | 0.85 | JAK3 (0.68) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21601023 | 0.84 | JAK3 (0.71) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21601005 | 0.84 | JAK3 (0.71) | JAK3TTKEGFRJAK2JAK1 | |
| SCHEMBL21600965 | 0.82 | JAK3 (0.60) | JAK3TTKEGFRFLT3BLK | |
| SCHEMBL21600966 | 0.81 | JAK3 (0.57) | JAK3TTKEGFRJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |