Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TXK | P42681 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600900 | 0.93 | FGFR1 (0.48) | JAK3FGFR1FGFR2FGFR4EGFR | |
| SCHEMBL21600969 | 0.92 | JAK3 (0.53) | JAK3FGFR1FGFR2CTSCJAK1 | |
| SCHEMBL21601024 | 0.88 | JAK3 (0.51) | JAK3FGFR1FGFR2CTSCJAK1 | |
| SCHEMBL21601004 | 0.88 | JAK3 (0.61) | JAK3FGFR1JAK1MAP3K7FGFR4 | |
| SCHEMBL21601016 | 0.87 | JAK3 (0.48) | JAK3FGFR1FGFR2CTSCJAK1 | |
| SCHEMBL21600962 | 0.86 | JAK3 (0.56) | JAK3FGFR1FGFR2CTSCJAK1 | |
| SCHEMBL21600918 | 0.86 | FGFR1 (0.49) | JAK3FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21600906 | 0.86 | FGFR1 (0.49) | JAK3FGFR1FGFR2FGFR4EGFR | |
| SCHEMBL21600963 | 0.86 | MAP3K7 (0.50) | JAK3FGFR1FGFR2CTSCJAK1 | |
| SCHEMBL21601014 | 0.85 | JAK3 (0.52) | JAK3FGFR1FGFR2CTSCJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |