Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21604217 | 0.86 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21603707 | 0.84 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21597466 | 0.81 | KDM4E (0.53) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21597710 | 0.80 | KDM4E (0.69) | SMN1; SMN2MAPTKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5455799 | 0.80 | FLT3 (0.68) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21597119 | 0.79 | REV1 (0.53) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21603968 | 0.79 | KDM4E (0.71) | NPC1RAB9AMAPTKDM4EHSD17B10 | |
| SCHEMBL21603848 | 0.77 | CNR2 (0.53) | SMN1; SMN2MAPTKDM4EHSD17B10REV1 | |
| SCHEMBL21597113 | 0.76 | CNR2 (0.50) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21603632 | 0.73 | MAPT (0.60) | NPC1RAB9ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |