REV1

DNA repair protein REV1 · Q9UBZ9 · REV1 on Sugi Atlas →

4,433 patent compounds predicted against REV1, 2,808 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL673606 SCHEMBL673606 0.33 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1373922) 0.63 2/20
SCHEMBL3396020 SCHEMBL3396020 0.59 2/20
SCHEMBL1734029 SCHEMBL1734029 0.59 2/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1736301) 0.59 2/20
SCHEMBL1109178 SCHEMBL1109178 0.56 2/20
SCHEMBL1109382 SCHEMBL1109382 0.55 2/20
SCHEMBL1373823 SCHEMBL1373823 0.55 2/20
SCHEMBL1373826 SCHEMBL1373826 0.55 2/20
SCHEMBL1109346 SCHEMBL1109346 0.54 2/20
SCHEMBL3161698 SCHEMBL3161698 0.53 2/20
SCHEMBL403077 SCHEMBL403077 0.53 2/20
SCHEMBL79038 SCHEMBL79038 0.53 2/20
SCHEMBL1912247 SCHEMBL1912247 0.53 2/20
SCHEMBL400947 SCHEMBL400947 0.52 2/20
SCHEMBL1372466 SCHEMBL1372466 0.52 2/20
SCHEMBL1372470 SCHEMBL1372470 0.52 2/20
SCHEMBL2171705 SCHEMBL2171705 0.52 2/20
SCHEMBL1734028 SCHEMBL1734028 0.51 2/20
SCHEMBL1373140 SCHEMBL1373140 0.51 2/20

Clinical trials — most relevant to REV1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
S0720: Adjuvant Therapy Based on Gene Expression in Stage IA and IB Non-Small Cell Lung Cancer PHASE2COMPLETED
Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer PHASE2WITHDRAWN
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction PHASE2COMPLETED
Satraplatin and Prednisone to Treat Prostate Cancer PHASE2COMPLETED
Phase II ABT-888 With Cyclophosphamide PHASE2COMPLETED
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies PHASE1/PHASE2RECRUITING
Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer PHASE2ACTIVE_NOT_RECRUITING
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas PHASE1COMPLETED
Veliparib and Radiation Therapy in Treating Patients With Advanced Solid Malignancies With Peritoneal Carcinomatosis, Epithelial Ovarian, Fallopian, or Primary Peritoneal Cancer PHASE1COMPLETED
Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor, in Combination With Cisplatin in People With Refractory Solid Tumors PHASE1COMPLETED
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors PHASE1COMPLETED
Indenoisoquinoline LMP400 for Advanced Solid Tumors and Lymphomas PHASE1COMPLETED
Nucleoside Therapy in Patients With Telomere Biology Disorders PHASE1RECRUITING
A Phase I Trial of SHR3162 in Subjects With Advanced Solid Tumors PHASE1COMPLETED
Gemcitabine and Radiation Therapy in Treating Patients With Locally Advanced Upper Gastrointestinal Cancer PHASE1COMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients nanCOMPLETED
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
Thymidine Kinase 1 in Risk Assessment for Hereditary Breast /Ovarian Cancer nanUNKNOWN
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC nanUNKNOWN
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease nanCOMPLETED
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy nanUNKNOWN
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia nanNOT_YET_RECRUITING
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors nanCOMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Pesticide Associated Lymphomas: Expression of Treatment Resistance Genes nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome) nanCOMPLETED
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a REV1 binder may also engage these)

ProteinNameSimilarity
Q5R4N7 1.000 Q5R4N7 →
Q920Q2 1.000 Q920Q2 →
Q4KWZ7 0.999 Q4KWZ7 →
Q6R3M4 0.982 Q6R3M4 →
Q8H2D5 0.981 Q8H2D5 →
POLI DNA polymerase iota 0.981 landscape →
F6RIX4 0.976 F6RIX4 →
ERCC5 DNA excision repair protein ERCC-5 0.976 landscape →
Q99MU3 0.975 Q99MU3 →
Q7TPQ3 0.975 Q7TPQ3 →
Q5XIX3 0.975 Q5XIX3 →
I0IUP4 0.974 I0IUP4 →
F1N2W9 0.974 F1N2W9 →
F1QDI9 0.973 F1QDI9 →
O60934 0.973 O60934 →
Q7TN31 0.972 Q7TN31 →
Q69Z66 0.972 Q69Z66 →
P14629 0.972 P14629 →
Q9BY84 0.972 Q9BY84 →
Q8K4J0 0.972 Q8K4J0 →
Q5RCV3 0.972 Q5RCV3 →
Q9DG67 0.972 Q9DG67 →
P55266 0.972 P55266 →
O88974 0.971 O88974 →
G9CGD6 0.971 G9CGD6 →
Q9QXK2 0.971 Q9QXK2 →
Q5R6Z9 0.971 Q5R6Z9 →
P35689 0.971 P35689 →
Q9BWU0 0.970 Q9BWU0 →
Q6NRM6 0.970 Q6NRM6 →