Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5451004 | 0.83 | MAPT (0.77) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL3806687 | 0.81 | MAPT (0.77) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL21597279 | 0.80 | MAPT (0.51) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL3923517 | 0.80 | KDM4E (0.66) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL21597795 | 0.79 | ALDH1A1 (0.49) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL21597739 | 0.78 | MAPT (0.47) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL27418736 | 0.78 | MAPT (0.51) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL27418713 | 0.78 | ADORA1 (0.56) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL21603737 | 0.78 | KMT2A (0.52) | MAPTKDM4EHSD17B10ALDH1A1LMNA | |
| SCHEMBL5450835 | 0.76 | POLB (0.62) | MAPTKDM4EHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |