Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037264 | 0.78 | TDP1 (0.50) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL11229719 | 0.77 | TDP1 (0.53) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL6988522 | 0.76 | TDP1 (0.47) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL9149761 | 0.74 | TDP1 (0.47) | TDP1CASP3LMNAALDH1A1GAA | |
| SCHEMBL166122 | 0.72 | TDP1 (0.57) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL6656473 | 0.72 | TDP1 (0.57) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL29381145 | 0.72 | TDP1 (0.57) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL1892274 | 0.70 | TDP1 (0.55) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL27755640 | 0.69 | TDP1 (0.65) | TDP1CASP3LMNAALDH1A1HTT | |
| SCHEMBL9385959 | 0.69 | TDP1 (0.46) | TDP1CASP3LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |