Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REV1 | Q9UBZ9 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21603945 | 0.91 | REV1 (0.50) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21597869 | 0.88 | REV1 (0.48) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21604250 | 0.87 | REV1 (0.45) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21597477 | 0.86 | REV1 (0.44) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21603849 | 0.86 | REV1 (0.44) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21604011 | 0.84 | REV1 (0.45) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21597466 | 0.84 | KDM4E (0.53) | REV1KDM4EHSD17B10MAPTFLT3 | |
| SCHEMBL21603794 | 0.83 | REV1 (0.49) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL5455799 | 0.80 | FLT3 (0.68) | REV1KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL21603968 | 0.79 | KDM4E (0.71) | REV1KDM4EHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |