Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21603962 | 0.84 | KDM4E (0.35) | NPC1RAB9AKIF11ALDH1A1MEN1 | |
| SCHEMBL14156337 | 0.82 | CNR2 (0.53) | NPC1RAB9AALDH1A1CNR2MEN1 | |
| SCHEMBL21597113 | 0.82 | CNR2 (0.50) | NPC1RAB9AKIF11CNR2MEN1 | |
| SCHEMBL21603918 | 0.73 | ABCC1 (0.33) | NPC1RAB9ACNR2CNR1POLB | |
| SCHEMBL21597590 | 0.71 | ALDH1A1 (0.46) | ALDH1A1CNR2MEN1KMT2AKDM4E | |
| SCHEMBL21604015 | 0.68 | CNR2 (0.58) | ALDH1A1CNR2MEN1KMT2AKDM4E | |
| SCHEMBL21603998 | 0.68 | ALDH1A1 (0.39) | NPC1RAB9AKIF11ALDH1A1KDM4E | |
| SCHEMBL21597441 | 0.68 | MAPT (0.36) | NPC1RAB9AALDH1A1CNR2MEN1 | |
| SCHEMBL21603819 | 0.68 | ALDH1A1 (0.34) | NPC1RAB9AKIF11ALDH1A1MEN1 | |
| SCHEMBL28920828 | 0.68 | CNR2 (0.50) | NPC1RAB9AALDH1A1CNR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |