Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21606274 | 0.89 | STING1 (0.51) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21606287 | 0.84 | STING1 (0.46) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21606281 | 0.84 | RORC (0.39) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21606323 | 0.84 | SMN1; SMN2 (0.52) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21606289 | 0.83 | STING1 (0.53) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL22000590 | 0.83 | STING1 (0.49) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL22000894 | 0.83 | STING1 (0.72) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21932446 | 0.83 | STING1 (0.72) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL21932342 | 0.83 | STING1 (0.72) | STING1SMN1; SMN2MEN1KMT2AATM | |
| SCHEMBL31065605 | 0.83 | STING1 (0.72) | STING1SMN1; SMN2MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243823-A1 | AZAHETEROCYCLIC SMALL MOLECULE MODULATORS OF HUMAN STING | CURADEV PHARMA LIMITED (GB) | 2019-12-26 | — | — | WO | disclosed |