Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA7 | P43166 | 4/20 | 0.45 |
| ▸ | CA5A | P35218 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CA3 | P07451 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orcinol SCHEMBL28132603 | 0.85 | ALDH1A1 (0.63) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL12275034 | 0.85 | BACE1 (0.61) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL28317060 | 0.81 | BACE1 (0.57) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL28422442 | 0.81 | BACE1 (0.57) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL12275471 | 0.81 | BACE1 (0.57) | BACE1LCKCA12CA9CA2 | |
| Resorcinol SCHEMBL21623723 | 0.81 | ALDH1A1 (0.71) | LCKCA12CA9CA2CA14 | |
| Formic Acid SCHEMBL2160962 | 0.81 | KDM4E (0.42) | BACE1CA12CA9CA2CA14 | |
| Phloroglucinol SCHEMBL2889628 | 0.78 | BACE1 (1.00) | BACE1LCKCA12CA9CA2 | |
| Phloroglucinol SCHEMBL26311 | 0.78 | — | — | |
| Phloroglucinol SCHEMBL30542958 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113308169-B | Water-based epoxy zinc-rich coating with good graphene dispersibility | 浙江省海洋开发研究院 | 2022-06-17 | — | — | CN | claimed |
| CN-113308169-A | Water-based epoxy zinc-rich coating with good graphene dispersibility | 浙江省海洋开发研究院 | 2021-08-27 | — | — | CN | claimed |
| CN-109054008-B | Polyester resin for anti-yellowing HAA system powder coating, preparation method and application | 黄山市徽州康佳化工有限责任公司 | 2021-01-01 | — | — | CN | claimed |
| CN-105377315-A | IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE USING COMPOUNDS INCLUDING TRIHYDROXYPHENYL GROUPS | BAXTER INT | 2016-03-02 | — | — | CN | claimed |
| CN-113308169-B | Water-based epoxy zinc-rich coating with good graphene dispersibility | 浙江省海洋开发研究院 | 2022-06-17 | — | — | CN | disclosed |
| CN-113308169-A | Water-based epoxy zinc-rich coating with good graphene dispersibility | 浙江省海洋开发研究院 | 2021-08-27 | — | — | CN | disclosed |
| CN-109054008-B | Polyester resin for anti-yellowing HAA system powder coating, preparation method and application | 黄山市徽州康佳化工有限责任公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-109054008-B | Polyester resin for anti-yellowing HAA system powder coating, preparation method and application | 黄山市徽州康佳化工有限责任公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-107987802-A | A kind of heat safe engine coolant | 中国石油化工股份有限公司 | 2018-05-04 | — | — | CN | disclosed |
| CN-107001637-A | Siloxane compounds and compositions thereof for treating amino acid-based substrates | 迈图高新材料股份有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106471071-A | Electrostatic ink compositionss | 惠普印迪戈股份公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-105377315-A | IMMOBILIZATION OF AN ACTIVE AGENT ON A SUBSTRATE USING COMPOUNDS INCLUDING TRIHYDROXYPHENYL GROUPS | BAXTER INT | 2016-03-02 | — | — | CN | disclosed |
| US-7985502-B2 | Containing formic ester additive; cycling properties, electrical capacity, storage during charging | UBE INDUSTRIES, LTD. (JP) | 2011-07-26 | — | — | US | disclosed |
| EP-1729365-B1 | NON-AQUEOUS ELECTROLYTE SOLUTION AND LITHIUM SECONDARY BATTERY USING THE SAME | UBE INDUSTRIES (JP) | 2010-12-22 | — | — | EP | disclosed |
| US-20080241704-A1 | Nonaqueous Electrolyte Solution and Lithium Secondary Battery Using Same | UBE INDUSTRIES, LTD (JP) | 2008-10-02 | — | — | US | disclosed |
| EP-1729365-A1 | NONAQUEOUS ELECTROLYTE SOLUTION AND LITHIUM SECONDARY BATTERY USING SAME | Ube Industries, Ltd. (JP) | 2006-12-06 | — | — | EP | disclosed |