Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318993 | 0.83 | MAPT (0.68) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL31382898 | 0.81 | NPC1 (0.59) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL9885183 | 0.81 | MAPT (0.48) | NPC1MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL4309629 | 0.76 | MAPT (0.62) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL23579367 | 0.74 | NPC1 (0.54) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL31520383 | 0.74 | NPC1 (0.56) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL31520385 | 0.74 | NPC1 (0.56) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL25641831 | 0.73 | TDP1 (0.44) | NPC1MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL3959791 | 0.73 | MAPT (0.53) | NPC1MAPTKMT2AMEN1CRHBP | |
| SCHEMBL19790245 | 0.73 | KAT2B (0.38) | NPC1MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243535-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |