⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392753 | 0.71 | — | — | |
| SCHEMBL22667090 | 0.67 | — | — | |
| SCHEMBL22275385 | 0.67 | PDE4A (0.42) | — | |
| SCHEMBL16995203 | 0.67 | — | — | |
| SCHEMBL2074108 | 0.66 | — | — | |
| SCHEMBL27351230 | 0.64 | PDE4A (0.40) | — | |
| SCHEMBL19806345 | 0.64 | PDE4A (0.40) | — | |
| SCHEMBL16608603 | 0.62 | CHEK1 (0.36) | — | |
| SCHEMBL27344638 | 0.62 | ALDH1A1 (0.49) | — | |
| SCHEMBL11392877 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107683282-A | New URAT1 inhibitor and its application in medicine | 江苏新元素医药科技有限公司 | 2018-02-09 | — | — | CN | claimed |
| US-20250136606-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2025-05-01 | — | — | US | disclosed |
| EP-4408850-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | Caraway Therapeutics, Inc. (US) | 2024-08-07 | — | — | EP | disclosed |
| CN-118317963-A | TRPML modulators, compositions thereof, and methods of use | 卡拉韦治疗公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023055920-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. (US) | 2023-04-06 | — | — | WO | disclosed |
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-09 | — | — | US | disclosed |
| WO-2019243535-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| CN-107683282-A | New URAT1 inhibitor and its application in medicine | 江苏新元素医药科技有限公司 | 2018-02-09 | — | — | CN | disclosed |