Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18363435 | 0.75 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363208 | 0.75 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363279 | 0.74 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL28523558 | 0.74 | GRIN2B (0.77) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363437 | 0.73 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363317 | 0.72 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9 | |
| SCHEMBL18363327 | 0.72 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL28523293 | 0.72 | GRIN2B (0.61) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363436 | 0.72 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 | |
| SCHEMBL18363470 | 0.72 | GRIN2B (1.00) | GRIN2BGRIN1KCNH2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |