Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613442 | 0.84 | PSMB5 (0.44) | PDGFRBPDGFRAGRIN2BMAP4K4 | |
| SCHEMBL21613456 | 0.79 | PDGFRB (0.40) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL21613439 | 0.77 | MAP4K4 (0.42) | GRIN2BGRIN1MAP4K4EGLN1 | |
| SCHEMBL21613463 | 0.75 | GRIN2B (0.41) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL17016707 | 0.75 | MAP4K4 (0.44) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL21613520 | 0.72 | GRIN2B (0.41) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL21613474 | 0.71 | GRIN2B (0.40) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL21613466 | 0.71 | GRIN2B (0.40) | PDGFRBPDGFRAGRIN2BGRIN1MAP4K4 | |
| SCHEMBL20049775 | 0.70 | NPC1 (0.42) | PDGFRBPDGFRAGRIN2BGRIN1CHRNA7 | |
| SCHEMBL25583779 | 0.69 | CHRNA7 (0.49) | PDGFRBPDGFRAGRIN2BFYNCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |