Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613439 | 0.86 | MAP4K4 (0.42) | MAP4K4GRIN2B | |
| SCHEMBL21613440 | 0.84 | PDGFRB (0.39) | MAP4K4PDGFRBPDGFRAGRIN2B | |
| SCHEMBL21613490 | 0.79 | PSMB5 (0.46) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL21613445 | 0.78 | PSMB5 (0.45) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL23319558 | 0.75 | PSMB5 (0.43) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL21613606 | 0.73 | PSMB5 (0.44) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL18136475 | 0.72 | PSMB5 (0.53) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL23280596 | 0.71 | PSMB5 (0.45) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL10205844 | 0.71 | PSMB5 (0.51) | PSMB5GSK3BGSK3AMAPTCASP1 | |
| SCHEMBL13141949 | 0.69 | PSMB5 (0.50) | PSMB5GSK3BGSK3AMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |