Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 1.00 |
| ▸ | GABRB2 | P47870 | 6/20 | 1.00 |
| ▸ | G6PD | P11413 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 4/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 4/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | GABRA2 | P47869 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GLA | P06280 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | GABRP | O00591 | 2/20 | 0.70 |
| ▸ | GABRD | O14764 | 2/20 | 0.70 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.70 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.70 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.70 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.70 |
| ▸ | GABRE | P78334 | 2/20 | 0.70 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alfaxalone SCHEMBL644125 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL350372 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL643098 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL24766358 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL21614107 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL24675016 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL21614053 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL24765814 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL21614074 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 | |
| Alfaxalone SCHEMBL9809348 | 1.00 | GABRA1 (1.00) | GABRA1GABRB2G6PDCYP3A4GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020006596-A1 | NEUROACTIVE STEROIDS AND METHODS OF PREPARATION | DRAWBRIDGE PHARMACEUTICALS PTY LTD (AU) | 2020-01-09 | — | — | WO | disclosed |