Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21616837 | 0.92 | TSHR (0.48) | TSHRGFERMEN1KMT2ANPC1 | |
| SCHEMBL21616821 | 0.90 | TSHR (0.47) | TSHRGFERMEN1KMT2ANPC1 | |
| SCHEMBL4069514 | 0.81 | SIGMAR1 (0.44) | MEN1KMT2ANPC1SIGMAR1HRH3 | |
| SCHEMBL14304586 | 0.81 | MEN1 (0.47) | MEN1KMT2ANPC1SIGMAR1HRH3 | |
| SCHEMBL21616826 | 0.78 | BACE1 (0.59) | MEN1KMT2A | |
| SCHEMBL5128357 | 0.78 | SIGMAR1 (0.44) | TSHRGFERMEN1KMT2ANPC1 | |
| SCHEMBL2696438 | 0.77 | SIGMAR1 (0.42) | GFERMEN1KMT2ANPC1SIGMAR1 | |
| SCHEMBL23671489 | 0.77 | BACE1 (0.58) | — | |
| SCHEMBL23671493 | 0.77 | BACE1 (0.58) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL31033187 | 0.76 | SIGMAR1 (0.48) | TSHRMEN1KMT2ASIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230131-A1 | POLYAMINO BIARYL COMPOUNDS AND THEIR USE | CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) (FR) | 2021-07-29 | — | — | US | disclosed |
| EP-3820862-A1 | POLYAMINO BIARYL COMPOUNDS AND THEIR USE | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020011848-A1 | POLYAMINO BIARYL COMPOUNDS AND THEIR USE | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-01-16 | — | — | WO | disclosed |
| WO-2020011848-A1 | POLYAMINO BIARYL COMPOUNDS AND THEIR USE | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230131-A1 | POLYAMINO BIARYL COMPOUNDS AND THEIR USE | ABCG2, SLC10A1, CYP3A43 | TSHR 3987/4885GFER 3142/4885MEN1 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.