SCHEMBL21617157

SCHEMBL21617157

O=C(CCC1CCCCC1)Nc1cccc(Nc2ccc(OCc3ccccc3)cc2C2CCCC2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ ALDH1A1 P00352 3/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ CYP2C9 P11712 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ LDLR P01130 2/20 0.45
▸ CTSV O60911 1/20 0.44
▸ CTSL P07711 1/20 0.44
▸ LTA4H P09960 1/20 0.43
▸ SIRT2 Q8IXJ6 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.42
▸ KLK7 P49862 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ NFKB1 P19838 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504354 1.00 HPGD (0.48) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617168 0.91 ALDH1A1 (0.47) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617284 0.89 F10 (0.47) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617249 0.89 LDLR (0.52) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL31504368 0.89 LDLR (0.52) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL31504312 0.89 HPGD (0.48) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617289 0.89 HPGD (0.48) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617239 0.87 KDM4E (0.49) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL21617260 0.87 HPGD (0.47) HPGDKDM4EALDH1A1MEN1KMT2A
SCHEMBL31504331 0.87 KDM4E (0.49) HPGDKDM4EALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
EP-3820850-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-05-19 — — EP disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R HPGD 3998/4885KDM4E 1489/4885ALDH1A1 3246/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R HPGD 3998/4885KDM4E 1489/4885ALDH1A1 3246/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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