Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 4/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21621425 | 0.84 | LMNA (0.38) | MAPK1CD274ABL1TDP1 | |
| SCHEMBL5122723 | 0.83 | ABL1 (0.38) | CD274ABL1ATRCYP4F2CYP4A11 | |
| SCHEMBL28479530 | 0.81 | ATR (0.36) | CD274ABL1ATRPOLBCYP4F2 | |
| SCHEMBL16057646 | 0.80 | ABL1 (0.36) | CD274ABL1ATRPOLBCYP4F2 | |
| SCHEMBL15634393 | 0.79 | ATR (0.35) | CD274ABL1ATRRXRARXRB | |
| SCHEMBL32684090 | 0.79 | CYP2C19 (0.33) | CD274ABL1CYP4F2CYP4A11FLT3 | |
| SCHEMBL21570191 | 0.78 | POLB (0.39) | POLBTDP1BTK | |
| SCHEMBL22235605 | 0.77 | ELANE (0.39) | ABL1POLB | |
| SCHEMBL18209667 | 0.77 | ATR (0.36) | CD274ABL1ATRCYP4F2CYP4A11 | |
| SCHEMBL25189905 | 0.76 | CD274 (0.36) | CD274ABL1CYP4F2CYP4A11RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020011254-A1 | FUSED TRI-CYCLIC COMPOUND AS PDE3/PDE4 DUAL INHIBITOR | 正大天晴药业集团股份有限公司 | 2020-01-16 | — | — | WO | disclosed |