Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.56 |
| ▸ | IKZF2 | Q9UKS7 | 7/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27143832 | 0.88 | CRBN (0.53) | CRBNIKZF2IKZF1 | |
| SCHEMBL30718612 | 0.88 | CRBN (0.53) | CRBNIKZF2IKZF1 | |
| SCHEMBL27143837 | 0.88 | CRBN (0.53) | CRBNIKZF2IKZF1 | |
| SCHEMBL24745083 | 0.86 | CRBN (0.63) | CRBNIKZF2IKZF1 | |
| SCHEMBL30270874 | 0.86 | CRBN (0.63) | CRBNIKZF2IKZF1 | |
| SCHEMBL24079912 | 0.85 | IKZF2 (0.52) | CRBNIKZF2IKZF1 | |
| SCHEMBL21618188 | 0.85 | IKZF2 (0.52) | CRBNIKZF2IKZF1 | |
| SCHEMBL24080122 | 0.85 | IKZF2 (0.52) | CRBNIKZF2IKZF1 | |
| SCHEMBL21621900 | 0.85 | CRBN (0.54) | CRBNIKZF2IKZF1 | |
| SCHEMBL21622008 | 0.85 | IKZF2 (0.52) | CRBNIKZF2IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020012334-A1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2020-01-16 | — | — | WO | disclosed |