Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.58 |
| ▸ | TP53 | P04637 | 10/20 | 0.58 |
| ▸ | LMNA | P02545 | 12/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21626408 | 0.86 | MAPT (0.62) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL21623085 | 0.84 | MAPT (0.57) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL15076818 | 0.83 | MAPT (0.57) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL21327806 | 0.80 | MAPT (0.75) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL21623370 | 0.80 | MAPT (0.55) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL21623108 | 0.77 | MAPT (0.57) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL21623245 | 0.76 | MAPT (0.59) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL17457280 | 0.76 | LMNA (0.57) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL15076544 | 0.76 | LMNA (0.61) | MAPTTP53LMNASMN1; SMN2HTT | |
| SCHEMBL17465705 | 0.76 | LMNA (0.61) | MAPTTP53LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016434-A1 | CYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020016434-A1 | CYCLIC INHIBITORS OF HEPATITIS B VIRUS | OSPEDALE SAN RAFFAELE S.R.L. (IT) | 2020-01-23 | — | — | WO | disclosed |
| EP-3597653-A1 | CYCLIC INHIBITORS OF HEPATITIS B VIRUS | IRBM S.P.A. (IT) | 2020-01-22 | — | — | EP | disclosed |
| EP-3597653-A1 | CYCLIC INHIBITORS OF HEPATITIS B VIRUS | IRBM S.P.A. (IT) | 2020-01-22 | — | — | EP | disclosed |