Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.61 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147988 | 0.88 | PDCD1 (0.53) | CD274PDCD1S1PR1S1PR3ALDH1A1 | |
| SCHEMBL16245269 | 0.88 | PDCD1 (0.76) | CD274PDCD1S1PR1S1PR3GABRA1 | |
| SCHEMBL29724539 | 0.86 | PDCD1 (0.52) | CD274PDCD1S1PR1S1PR3ALDH1A1 | |
| SCHEMBL20540364 | 0.86 | PDCD1 (0.52) | CD274PDCD1S1PR1S1PR3ALDH1A1 | |
| SCHEMBL21616726 | 0.81 | ALDH1A1 (0.46) | CD274PDCD1S1PR1ALDH1A1MAPK1 | |
| SCHEMBL30340550 | 0.81 | ALDH1A1 (0.46) | CD274PDCD1S1PR1ALDH1A1MAPK1 | |
| SCHEMBL6029512 | 0.80 | PDCD1 (0.66) | CD274PDCD1S1PR1S1PR3ALDH1A1 | |
| SCHEMBL6027619 | 0.78 | PDCD1 (0.69) | CD274PDCD1S1PR1S1PR3MAPK1 | |
| SCHEMBL30255315 | 0.78 | PDCD1 (0.69) | CD274PDCD1S1PR1S1PR3MAPK1 | |
| SCHEMBL6424004 | 0.76 | PDCD1 (0.64) | CD274PDCD1GABRA1GABRB2APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111886219-B | Immunosuppressant, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-111886219-A | Immunosuppressant, preparation method and pharmaceutical application thereof | 上海和誉生物医药科技有限公司 | 2020-11-03 | — | — | CN | disclosed |
| WO-2020011209-A1 | IMMUNOSUPPRESSIVE AGENT, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2020-01-16 | — | — | WO | disclosed |