Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21623584 | 0.84 | EPHX2 (0.48) | LMNAEPHX2ALDH1A1TDP1MAPT | |
| SCHEMBL21626500 | 0.76 | MAPT (0.43) | LMNAEPHX2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL28340365 | 0.70 | ALDH1A1 (0.39) | LMNAALDH1A1TDP1MAPTTSHR | |
| SCHEMBL21623582 | 0.69 | MAPT (0.44) | LMNAEPHX2ALDH1A1TDP1MAPT | |
| SCHEMBL31352372 | 0.69 | MAPT (0.44) | LMNAEPHX2ALDH1A1TDP1MAPT | |
| SCHEMBL4427648 | 0.65 | ALDH1A1 (0.71) | ALDH1A1TDP1TSHRCYP3A4 | |
| SCHEMBL21603504 | 0.64 | ALDH1A1 (0.48) | ALDH1A1TDP1TSHRCYP3A4 | |
| SCHEMBL4923328 | 0.64 | ALDH1A1 (0.47) | LMNAALDH1A1TDP1MAPTTSHR | |
| SCHEMBL21623583 | 0.63 | EPHX2 (0.49) | LMNAEPHX2ALDH1A1MAPTKDM1A | |
| SCHEMBL27895758 | 0.63 | ALDH1A1 (0.47) | LMNAALDH1A1TDP1TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12152012-B2 | BRAG2 inhibitors and applications thereof | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2024-11-26 | — | — | US | disclosed |
| US-20210284620-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | INSTITUT CURIE (10% PART INTEREST) (FR) | 2021-09-16 | — | — | US | disclosed |
| US-20210284620-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | INSTITUT CURIE (10% PART INTEREST) (FR) | 2021-09-16 | — | — | US | disclosed |
| EP-3823612-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | Centre National de la Recherche Scientifique (FR) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020016239-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-01-23 | — | — | WO | disclosed |
| EP-3597187-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210284620-A1 | BRAG2 INHIBITORS AND APPLICATIONS THEREOF | ING2, BRAP, BRWD1 | LMNA 4610/4885EPHX2 1545/4885ALDH1A1 3962/4885 |
| US-12152012-B2 | BRAG2 inhibitors and applications thereof | ING2, BRAP, BRWD1 | LMNA 4610/4885EPHX2 1545/4885ALDH1A1 3962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.