Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21623768 | 0.84 | MDM2 (0.48) | SMN1; SMN2MDM2PKMHTTPOLB | |
| SCHEMBL3254366 | 0.74 | ALDH1A1 (0.71) | POLBTDP1MAPTTXNRD1ALDH1A1 | |
| SCHEMBL5321454 | 0.73 | MAPT (0.57) | SMN1; SMN2MDM2MEN1KMT2ATDP1 | |
| SCHEMBL21623748 | 0.70 | ALDH1A1 (0.39) | SMN1; SMN2MDM2POLBMEN1KMT2A | |
| SCHEMBL12466455 | 0.70 | ALDH1A1 (0.39) | SMN1; SMN2MDM2POLBMEN1KMT2A | |
| SCHEMBL21623756 | 0.70 | MAPT (0.45) | SMN1; SMN2MDM2MEN1KMT2AMAPT | |
| SCHEMBL21623764 | 0.70 | HTT (0.50) | SMN1; SMN2MDM2PKMHTTPOLB | |
| SCHEMBL21623731 | 0.69 | MEN1 (0.51) | SMN1; SMN2POLBMEN1KMT2AMAPT | |
| SCHEMBL21623750 | 0.69 | KMT2A (0.48) | SMN1; SMN2PKMPOLBMEN1KMT2A | |
| SCHEMBL2258709 | 0.69 | TSHR (0.44) | SMN1; SMN2MEN1KMT2ATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016297-A1 | THIOETHERS AS MODULATORS OF KV7.2/KV7.3 CHANNELS | Universität Greifswald (DE) | 2020-01-23 | — | — | WO | disclosed |