Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 4/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.52 |
| ▸ | CCNK | O75909 | 3/20 | 0.52 |
| ▸ | CCND3 | P30281 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21625799 | 0.84 | PTK2 (0.66) | ALKPTK2 | |
| SCHEMBL29904638 | 0.75 | CCNA2 (0.76) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL30395234 | 0.69 | CCNA2 (1.00) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL30394492 | 0.69 | CCNA2 (1.00) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL28459543 | 0.69 | CCNA2 (1.00) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL25480052 | 0.68 | MAP3K7 (0.80) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL13300671 | 0.68 | PKMYT1 (0.70) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL23200452 | 0.67 | CDK2 (0.80) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL25668162 | 0.67 | EGFR (0.81) | CCNA2CDK2CCNKCCND3CDK9 | |
| SCHEMBL13320642 | 0.67 | MAP3K7 (0.64) | CCNA2CDK2CCNKCCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3823613-A1 | DEGRADERS THAT TARGET PROTEINS VIA KEAP1 | Dana Farber Cancer Institute, Inc. (US) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020018788-A1 | DEGRADERS THAT TARGET PROTEINS VIA KEAP1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-01-23 | — | — | WO | disclosed |