Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 6/20 | 0.76 |
| ▸ | CDK2 | P24941 | 6/20 | 0.76 |
| ▸ | CDK9 | P50750 | 5/20 | 0.76 |
| ▸ | CCNK | O75909 | 4/20 | 0.76 |
| ▸ | CCND3 | P30281 | 4/20 | 0.76 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.76 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.60 |
| ▸ | WEE1 | P30291 | 3/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | PAK4 | O96013 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30395234 | 0.87 | CCNA2 (1.00) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL29904686 | 0.78 | CCNK (0.60) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL30394635 | 0.76 | CCNA2 (1.00) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL23409097 | 0.75 | CCNA2 (1.00) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL30394835 | 0.75 | CCNA2 (1.00) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL1606279 | 0.75 | ALK (0.49) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL1878922 | 0.75 | ALK (0.49) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL21625798 | 0.75 | CCNA2 (0.52) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL3767432 | 0.75 | ALK (1.00) | CCNA2CDK2CDK9CCNKCCND3 | |
| SCHEMBL30395236 | 0.74 | CCNA2 (1.00) | CCNA2CDK2CDK9CCNKCCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228458-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | THERAPEX CO., LTD. (KR) | 2024-07-11 | — | — | US | claimed |
| EP-4286376-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | Therapex Co., Ltd. (KR) | 2023-12-06 | — | — | EP | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| US-20240228458-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | THERAPEX CO., LTD. (KR) | 2024-07-11 | — | — | US | disclosed |
| EP-4286376-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | Therapex Co., Ltd. (KR) | 2023-12-06 | — | — | EP | disclosed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228458-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | EGFR, ERBB2, ERBB3 | CCNA2 1307/4885CDK2 39/4885CDK9 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.