Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161982 | 0.84 | TRPA1 (0.58) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL13721525 | 0.84 | TRPA1 (0.58) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL28916127 | 0.82 | TRPA1 (0.57) | TRPA1SLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL28915633 | 0.82 | TRPA1 (0.57) | TRPA1SLC6A2TAAR1MAOASLC6A4 | |
| Boric Acid SCHEMBL28247762 | 0.78 | TRPA1 (0.52) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL353179 | 0.77 | TRPA1 (0.50) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL6427170 | 0.77 | TRPA1 (0.50) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL2604925 | 0.77 | TRPA1 (0.55) | TRPA1CYP1A2EPHX1TSHRSLC6A2 | |
| SCHEMBL7906029 | 0.77 | TRPA1 (0.50) | TRPA1CYP1A2EPHX1TSHRALPI | |
| SCHEMBL29822049 | 0.77 | TRPA1 (0.50) | TRPA1CYP1A2EPHX1TSHRALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3823974-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020018975-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |