SCHEMBL21627022

SCHEMBL21627022

COC(=O)/C(=C\c1c(C)cc(N)cc1C)NC(C)=O

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ALDH1A1 P00352 5/20 0.33
▸ KDM4E B2RXH2 3/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ POLB P06746 1/20 0.30
▸ HPGD P15428 2/20 0.30
▸ LMNA P02545 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10477390 0.85 CYP3A4 (0.40) MEN1KMT2AALDH1A1HPGDLMNA
SCHEMBL16869910 0.82 KMT2A (0.39) MEN1KMT2AALDH1A1KDM4EPOLB
SCHEMBL2165649 0.79 MEN1 (0.46) MEN1KMT2AALDH1A1KDM4EHPGD
SCHEMBL1206815 0.74 MEN1 (0.40) MEN1KMT2AALDH1A1KDM4EPOLB
SCHEMBL5231447 0.74 MEN1 (0.40) MEN1KMT2AALDH1A1KDM4EPOLB
SCHEMBL3914299 0.74 NPSR1 (0.45) MEN1KMT2AALDH1A1KDM4ENPSR1
SCHEMBL3914295 0.74 NPSR1 (0.45) MEN1KMT2AALDH1A1KDM4ENPSR1
SCHEMBL2165525 0.73 KMT2A (0.42) MEN1KMT2AALDH1A1KDM4EPOLB
SCHEMBL10477373 0.73 HPGD (0.40) MEN1KMT2AALDH1A1POLBHPGD
SCHEMBL2166094 0.73 MEN1 (0.43) MEN1KMT2AALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10696716-B2 Pharmaceutically relevant aromatic-cationic peptides STEALTH BIOTHERAPEUTICS CORP (MC) 2020-06-30 — — US disclosed
US-20200024308-A1 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES STEALTH BIOTHERAPEUTICS CORP (MC) 2020-01-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200024308-A1 PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES ADM2, VIP, ANPEP MEN1 433/4885KMT2A 694/4885ALDH1A1 4716/4885
US-10696716-B2 Pharmaceutically relevant aromatic-cationic peptides ADM2, VIP, ANPEP MEN1 433/4885KMT2A 694/4885ALDH1A1 4716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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