SCHEMBL21628245

SCHEMBL21628245

CCCCCCc1c(Nc2ccccc2)cnc(N)c1CCCCCC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 11/20 0.46
MAPT P10636 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HSD17B10 Q99714 2/20 0.44
LMNA P02545 2/20 0.44
XBP1 P17861 1/20 0.44
HTT P42858 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
KCNH3 Q9ULD8 1/20 0.43
TLR7 Q9NYK1 3/20 0.41
DHFR P00374 1/20 0.39
HTR2A P28223 1/20 0.37
KDM4E B2RXH2 2/20 0.36
MEN1 O00255 2/20 0.36
ALDH1A1 P00352 2/20 0.36
GAA P10253 2/20 0.36
KMT2A Q03164 2/20 0.36
USP2 O75604 1/20 0.36
HPGD P15428 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29390314 0.79 HTT (0.44) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL29389963 0.79 HTT (0.44) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL29899667 0.77 HTT (0.45) MAPTSMN1; SMN2HSD17B10LMNAXBP1
SCHEMBL1810942 0.77 MAPT (0.42) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL28292241 0.73 MAPT (0.44) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL28232186 0.73 MAPT (0.44) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL7098349 0.73 MAPT (0.44) MAPTSMN1; SMN2HSD17B10LMNAXBP1
N,N'-Diphenyl-P-Phenylenediamine SCHEMBL1415255 0.72 MAPT (0.48) TLR8MAPTSMN1; SMN2HSD17B10LMNA
SCHEMBL31038833 0.71 LIPG (0.45) MAPTSMN1; SMN2HSD17B10LMNAXBP1
SCHEMBL29770056 0.71 LIPG (0.45) MAPTSMN1; SMN2HSD17B10LMNAXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230392018-A1 COMPOSITIONS COMPRISING LEUCO COMPOUNDS AND COLORANTS MILLIKEN & COMPANY 2023-12-07 US disclosed
EP-4237498-A1 COMPOSITIONS COMPRISING LEUCO COMPOUNDS AND COLORANTS Milliken & Company (US) 2023-09-06 EP disclosed
WO-2022093189-A1 COMPOSITIONS COMPRISING LEUCO COMPOUNDS AND COLORANTS MILLIKEN & COMPANY (US) 2022-05-05 WO disclosed
US-11261403-B2 Stabilized compositions comprising leuco compounds MILLIKEN & COMPANY (US) 2022-03-01 US disclosed
US-11136535-B2 Leuco colorants as bluing agents in laundry care compositions THE PROCTER & GAMBLE COMPANY (US) 2021-10-05 US disclosed
EP-3830232-A1 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS The Procter & Gamble Company (US) 2021-06-09 EP disclosed
US-20200032173-A1 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS THE PROCTER & GAMBLE COMPANY 2020-01-30 US disclosed
WO-2020023812-A1 LEUCO COLORANTS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2020-01-30 WO disclosed
US-20200032167-A1 STABILIZED COMPOSITIONS COMPRISING LEUCO COMPOUNDS MILLIKEN & COMPANY 2020-01-30 US disclosed