Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | BRD1 | O95696 | 1/20 | 0.35 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21628325 | 0.77 | BRD4 (0.56) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL21649918 | 0.70 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983266 | 0.70 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983297 | 0.70 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983263 | 0.70 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL19456317 | 0.70 | BRD4 (0.62) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL19437394 | 0.69 | BRD4 (0.80) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL20983252 | 0.69 | BRD4 (0.74) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL19456353 | 0.69 | BRD4 (0.74) | BRD4TRIM24BRD1CCL2DRD2 | |
| SCHEMBL28685842 | 0.68 | BRD4 (0.80) | BRD4TRIM24BRD1CCL2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |