Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357202 | 0.83 | CA9 (0.61) | MAPTCA9ALDH1A1KMT2AGAA | |
| SCHEMBL9979716 | 0.81 | CNR1 (0.61) | MAPTCA9ALDH1A1KMT2AGAA | |
| SCHEMBL28248773 | 0.81 | SMN1; SMN2 (0.58) | ALDH1A1KMT2ATDP1POLBSMN1; SMN2 | |
| SCHEMBL18865871 | 0.81 | KMT2A (0.52) | MAPTCA9ALDH1A1KMT2AGAA | |
| SCHEMBL18542682 | 0.80 | KMT2A (0.54) | MAPTCA9ALDH1A1KMT2AGAA | |
| SCHEMBL15520448 | 0.78 | ALDH1A1 (0.60) | MAPTCA9ALDH1A1KMT2ARAB9A | |
| SCHEMBL22122122 | 0.77 | KMT2A (0.58) | MAPTCA9ALDH1A1KMT2AGAA | |
| SCHEMBL9203290 | 0.77 | CA9 (0.76) | MAPTCA9ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9203679 | 0.77 | CHRNA7 (0.77) | MAPTCA9KMT2ASMN1; SMN2CHRNA7 | |
| SCHEMBL3702377 | 0.76 | NPSR1 (0.59) | MAPTALDH1A1KMT2AGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108570038-B | Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and application thereof | 中国科学院上海药物研究所 | 2021-09-28 | — | — | CN | disclosed |
| US-11078188-B2 | Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-08-03 | — | — | US | disclosed |
| US-20200031802-A1 | DIHYDROQUINOXALINE BROMODOMAIN RECOGNITION PROTEIN INHIBITOR, PREPARATION METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031802-A1 | DIHYDROQUINOXALINE BROMODOMAIN RECOGNITION PROTEIN INHIBITOR, PREPARATION METHOD AND USE THEREOF | BRD4, BRPF3, BRD1 | MAPT 2149/4885CA9 2400/4885ALDH1A1 3885/4885 |
| US-11078188-B2 | Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof | BRD4, BRPF3, BRD1 | MAPT 2149/4885CA9 2400/4885ALDH1A1 3885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.