Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | GCGR | P47871 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21633885 | 1.00 | RAB9A (0.60) | RAB9ANPC1AGTR1OPRK1NCOA3 | |
| SCHEMBL21649903 | 0.90 | NCOA3 (0.64) | RAB9ANPC1NCOA3SMN1; SMN2MEN1 | |
| SCHEMBL24023673 | 0.86 | NCOA3 (0.56) | RAB9ANPC1AGTR1OPRK1NCOA3 | |
| SCHEMBL12746295 | 0.76 | RAB9A (1.00) | RAB9ANPC1AGTR1OPRK1SMN1; SMN2 | |
| SCHEMBL13380986 | 0.75 | NCOA3 (0.77) | NCOA3KMT2AKDM4EHTTMAPT | |
| SCHEMBL782069 | 0.74 | NCOA3 (1.00) | NCOA3KDM4EHTTLMNAALDH1A1 | |
| SCHEMBL29773648 | 0.74 | NCOA3 (1.00) | NCOA3KDM4EHTTLMNAALDH1A1 | |
| SCHEMBL13927328 | 0.74 | NCOA3 (1.00) | NCOA3KDM4EHTTLMNAALDH1A1 | |
| SCHEMBL31237388 | 0.74 | NCOA3 (1.00) | NCOA3KDM4EHTTLMNAALDH1A1 | |
| SCHEMBL28484762 | 0.73 | RAB9A (0.74) | RAB9ANPC1AGTR1OPRK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355103-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2021-11-18 | — | — | US | disclosed |
| US-20210355103-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2021-11-18 | — | — | US | disclosed |
| WO-2020023802-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE (US) | 2020-01-30 | — | — | WO | disclosed |
| WO-2020023802-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE (US) | 2020-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355103-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | PARG, PARP12, PARN | RAB9A 2600/4885NPC1 1065/4885AGTR1 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.