Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eprenetapopt. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eprenetapopt SCHEMBL23726645 | 1.00 | MEN1 (0.72) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| Eprenetapopt SCHEMBL27272034 | 1.00 | MEN1 (0.72) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| Eprenetapopt SCHEMBL2228161 | 1.00 | MEN1 (0.72) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL29965401 | 0.94 | MEN1 (0.64) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL29965910 | 0.94 | MEN1 (0.64) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL29965601 | 0.94 | MEN1 (0.64) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL29965376 | 0.94 | MEN1 (0.64) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| Eprenetapopt SCHEMBL28990156 | 0.92 | MEN1 (0.60) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL30382084 | 0.91 | MEN1 (0.58) | MEN1MAPTCYP2C9CYP2C19KMT2A | |
| SCHEMBL23727096 | 0.91 | MEN1 (0.58) | MEN1MAPTCYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016155-A1 | METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING IN A SUBJECT SUFFERING FROM ECTODERMAL DYSPLASIAS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-01-23 | — | — | WO | disclosed |