Eprenetapopt

Eprenetapopt

SCHEMBL2228161

COCC1(CO)C(=O)C2CCN1CC2

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TP53

The experimentally established mechanism targets of Eprenetapopt. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.72
MAPT P10636 1/20 0.72
CYP2C9 P11712 1/20 0.72
CYP2C19 P33261 1/20 0.72
KMT2A Q03164 1/20 0.72
MMP3 P08254 1/20 0.30
MMP8 P22894 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eprenetapopt SCHEMBL21636035 1.00 MEN1 (0.72) MEN1MAPTCYP2C9CYP2C19KMT2A
Eprenetapopt SCHEMBL23726645 1.00 MEN1 (0.72) MEN1MAPTCYP2C9CYP2C19KMT2A
Eprenetapopt SCHEMBL27272034 1.00 MEN1 (0.72) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL29965401 0.94 MEN1 (0.64) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL29965910 0.94 MEN1 (0.64) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL29965601 0.94 MEN1 (0.64) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL29965376 0.94 MEN1 (0.64) MEN1MAPTCYP2C9CYP2C19KMT2A
Eprenetapopt SCHEMBL28990156 0.92 MEN1 (0.60) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL30382084 0.91 MEN1 (0.58) MEN1MAPTCYP2C9CYP2C19KMT2A
SCHEMBL23727096 0.91 MEN1 (0.58) MEN1MAPTCYP2C9CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 486 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3849310-B1 COMBINATION CANCER THERAPIES BASED ON THE MORTALIN TARGETING COMPOUND SHETA2 AND P53 REACTIVATORS OR CDK4/6 INHIBITORS UNIV OKLAHOMA (US) 2026-05-13 EP claimed
US-12521392-B2 Methods and compositions for promoting wound healing in a subject suffering from ectodermal dysplasias INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2026-01-13 US claimed
US-20260002222-A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF ALT CANCER TEXAS TECH UNIVERSITY SYSTEM (US) 2026-01-01 US claimed
US-20260000740-A1 USE OF A L-ASPARAGINASE IN COMBINATION WITH A FERROPTOSIS INDUCER FOR THE TREATMENT OF EXTRANODAL NATURAL KILLER/T-CELL LYMPHOMA INST NAT SANTE RECH MED (FR) 2026-01-01 US claimed
US-20260000697-A1 COMBINATION FORMULATION OF CEDAZURIDINE OTSUKA PHARMA CO LTD (JP) 2026-01-01 US claimed
US-20250345322-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS AROG PHARMACEUTICALS INC (US) 2025-11-13 US claimed
US-20250332150-A1 METHODS FOR TREATING NOTCH1-DRIVEN CANCERS INST NAT SANTE RECH MED (FR) 2025-10-30 US claimed
US-20250325548-A1 TUMOR SUPPRESSOR P73 TRANSCRIPTIONALLY REGULATES C-FLIP TO IMPEDE ITS PRIMING OF EXTRINSIC APOPTOSIS WHILE AN EXAMPLE SWITCHER COMPOUND CB-7587351 DEGRADES C-FLIP PROTEIN UNIV BROWN (US) 2025-10-23 US claimed
US-12435380-B2 Compositions and methods for the diagnosis and treatment of ALT cancer TEXAS TECH UNIVERSITY SYSTEM (US) 2025-10-07 US claimed
US-20250302863-A1 USE OF THBS1 INHIBITOR FOR OVERCOMING DRUG RESISTANCE IN CANCER KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2025-10-02 US claimed
WO-2021053155-A1 COMBINATION TREATMENT WITH A P53 REACTIVATOR AND AN INHIBITOR OF AN ANTIAPOPTOTIC BCL-2 FAMILY PROTEIN APREA THERAPEUTICS AB (SE) 2021-03-25 WO claimed
CN-106963759-B Aqueous solutions comprising 3-quinuclidinone derivatives for the treatment of hyperproliferative diseases, autoimmune diseases and cardiac diseases 阿普利亚治疗有限公司 2020-07-07 CN claimed
US-20170165240-A1 NEW STRATEGIES FOR TREATING MELANOMA Université Libre de Bruxelles (BE) 2017-06-15 US claimed
EP-3125940-A2 NEW STRATEGIES FOR TREATING MELANOMA Université Libre de Bruxelles (BE) 2017-02-08 EP claimed
EP-2525796-B1 Aqueous solution comprising 3-quinuclidinones for the treatment of hyperproliferative, autoimmune and heart disease APREA AB (SE) 2016-03-30 EP claimed
WO-2015150472-A2 NEW STRATEGIES FOR TREATING MELANOMA Université Libre de Bruxelles (BE) 2015-10-08 WO claimed
US-9061016-B2 Aqueous solution comprising 3-quinuclidinones for the treatment hyperproliferative, autoimmune and heart disease APREA AB (SE) 2015-06-23 US claimed
US-20120289503-A1 AQUEOUS SOLUTION COMPRISING 3 - QUINUCLIDINONES FOR THE TREATMENT HYPERPROLIFERATIVE, AUTOIMMUNE AND HEART DISEASE APREA AB (SE) 2012-11-15 US claimed
WO-2011089234-A2 METHOD AND COMPOSITION APREA AB (SE) 2011-07-28 WO claimed
EP-1727817-B1 AZABICYCLOOCTAN-3-ONE DERIVATIVES AND USE THEREOF APREA AB (SE) 2010-09-29 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250345322-A1 NOVEL COMBINATION THERAPY OF CRENOLANIB AND APOPTOSIS PATHWAY AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS CCAR2, BAX, DUSP22 MEN1 2618/4885MAPT 3662/4885CYP2C9 4813/4885
US-20170165240-A1 NEW STRATEGIES FOR TREATING MELANOMA TP53, BRAF, TP53BP1 MEN1 2962/4885MAPT 3637/4885CYP2C9 4881/4885
US-20260000697-A1 COMBINATION FORMULATION OF CEDAZURIDINE DCTD, EZH2, DUT MEN1 1769/4885MAPT 2747/4885CYP2C9 971/4885
US-20120289503-A1 AQUEOUS SOLUTION COMPRISING 3 - QUINUCLIDINONES FOR THE TREATMENT HYPERPROLIFERATIVE, AUTOIMMUNE AND HEART DISEASE IL17A, JAK1, JAK3 MEN1 242/4885MAPT 4069/4885CYP2C9 4604/4885
US-20260002222-A1 COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF ALT CANCER TERT, POT1, TELO2 MEN1 908/4885MAPT 442/4885CYP2C9 4503/4885
US-20250332150-A1 METHODS FOR TREATING NOTCH1-DRIVEN CANCERS TP53, NOTCH1, NOTCH4 MEN1 1202/4885MAPT 2787/4885CYP2C9 4197/4885
US-20250325548-A1 TUMOR SUPPRESSOR P73 TRANSCRIPTIONALLY REGULATES C-FLIP TO IMPEDE ITS PRIMING OF EXTRINSIC APOPTOSIS WHILE AN EXAMPLE SWITCHER COMPOUND CB-7587351 DEGRADES C-FLIP PROTEIN BCOR, CCAR2, CEBPZ MEN1 3174/4885MAPT 4116/4885CYP2C9 4518/4885
US-20260000740-A1 USE OF A L-ASPARAGINASE IN COMBINATION WITH A FERROPTOSIS INDUCER FOR THE TREATMENT OF EXTRANODAL NATURAL KILLER/T-CELL LYMPHOMA ERAP1, AIFM2, ERAL1 MEN1 3842/4885MAPT 4764/4885CYP2C9 4256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.