Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 4/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17045302 | 0.76 | CYP11B1 (0.40) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL20621312 | 0.76 | CYP11B1 (0.41) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL24907834 | 0.76 | CYP11B1 (0.41) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL19432291 | 0.71 | DRD4 (0.39) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL18463619 | 0.71 | DRD4 (0.42) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL6842210 | 0.71 | CYP11B1 (0.44) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL20412605 | 0.71 | CYP11B1 (0.44) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL16469651 | 0.70 | — | — | |
| SCHEMBL20861635 | 0.69 | CYP11B1 (0.43) | DRD4DRD3CYP11B1CYP11B2LRRK2 | |
| SCHEMBL23104465 | 0.69 | DRD4 (0.38) | DRD4DRD3CYP11B1CYP11B2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020018975-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020018970-A1 | SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |