Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320765 | 0.78 | CYP3A4 (0.56) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 | |
| SCHEMBL16320766 | 0.78 | CYP3A4 (0.56) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 | |
| SCHEMBL16321797 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTCYP3A4CYP2B6MEN1 | |
| SCHEMBL16321796 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2HTTCYP3A4CYP2B6MEN1 | |
| SCHEMBL16321911 | 0.66 | CYP3A4 (0.58) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 | |
| SCHEMBL16321912 | 0.66 | CYP3A4 (0.58) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 | |
| SCHEMBL31359061 | 0.66 | GPR139 (0.56) | SMN1; SMN2HTTMEN1KMT2ANPC1 | |
| SCHEMBL31359009 | 0.66 | GPR139 (0.56) | SMN1; SMN2HTTMEN1KMT2ANPC1 | |
| SCHEMBL16321187 | 0.65 | CYP3A4 (0.56) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 | |
| SCHEMBL16321188 | 0.65 | CYP3A4 (0.56) | SMN1; SMN2HTTALOX5CYP3A4CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |