Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21638663 | 0.92 | BRD4 (0.43) | BRD4IDH1GPER1NAMPTCREBBP | |
| SCHEMBL21638698 | 0.89 | BRD4 (0.43) | BRD4GSK3BDYRK1AKITPIK3CA | |
| SCHEMBL21638666 | 0.87 | BRD4 (0.51) | BRD4IDH1GSK3BDYRK1AWNT1 | |
| SCHEMBL16721676 | 0.84 | BRD4 (0.49) | BRD4IDH1GPER1NAMPTCREBBP | |
| SCHEMBL21638641 | 0.84 | BRD4 (0.60) | BRD4GSK3BDYRK1AWNT1KHK | |
| SCHEMBL21638456 | 0.84 | BRD4 (0.49) | BRD4IDH1GPER1NAMPTCREBBP | |
| SCHEMBL21638694 | 0.83 | BRD4 (0.51) | BRD4GSK3BDYRK1ACREBBP | |
| SCHEMBL16721952 | 0.83 | BRD4 (0.55) | BRD4IDH1GSK3BDYRK1AWNT1 | |
| SCHEMBL16722015 | 0.83 | BRD4 (0.57) | BRD4IDH1GPER1NAMPTCREBBP | |
| SCHEMBL16722013 | 0.83 | BRD4 (0.57) | BRD4IDH1GPER1NAMPTCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | disclosed |