Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | TTK | P33981 | 7/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21638731 | 0.92 | BRD4 (0.42) | BRD4TTKABL1KITPIK3CA | |
| SCHEMBL21638718 | 0.89 | BRD4 (0.44) | BRD4GSK3BDYRK1AKITPIK3CA | |
| SCHEMBL21638666 | 0.85 | BRD4 (0.51) | BRD4GSK3BDYRK1A | |
| SCHEMBL16721136 | 0.85 | BRD4 (0.48) | BRD4TTKHCRTR1HCRTR2KIT | |
| SCHEMBL21638444 | 0.84 | BRD4 (0.47) | BRD4TTKHCRTR1HCRTR2KIT | |
| SCHEMBL16722521 | 0.83 | BRD4 (0.54) | BRD4TTKGSK3BDYRK1AHCRTR1 | |
| SCHEMBL16722220 | 0.83 | BRD4 (0.55) | BRD4TTKHCRTR1HCRTR2KIT | |
| SCHEMBL16721515 | 0.83 | BRD4 (0.55) | BRD4TTKHCRTR1HCRTR2KIT | |
| SCHEMBL21638641 | 0.83 | BRD4 (0.60) | BRD4GSK3BDYRK1A | |
| SCHEMBL21638694 | 0.82 | BRD4 (0.51) | BRD4GSK3BDYRK1AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | disclosed |