Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.65 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.65 |
| ▸ | OXTR | P30559 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351064 | 0.89 | MEN1 (0.66) | KMT2AMEN1 | |
| SCHEMBL7348349 | 0.85 | AVPR2 (0.76) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL29463754 | 0.85 | ALDH1A1 (0.81) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL6198498 | 0.85 | ALDH1A1 (0.81) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL4493929 | 0.84 | ALDH1A1 (0.71) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL7349843 | 0.83 | AVPR2 (0.72) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL6965406 | 0.83 | AVPR2 (0.92) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL3456488 | 0.83 | HPGD (0.83) | ALDH1A1TSHRAVPR2AVPR1AOXTR | |
| SCHEMBL31680509 | 0.80 | HPGD (0.90) | ALDH1A1AVPR2AVPR1AOXTRHPGD | |
| SCHEMBL3136427 | 0.80 | POLB (0.73) | ALDH1A1TSHRAVPR2AVPR1AOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534676-B1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| US-7985760-B2 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-07-26 | — | — | US | disclosed |
| US-20060058349-A1 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | OXFORD GLYCOSCIENCES(UK) LTD (GB) | 2006-03-16 | — | — | US | disclosed |
| EP-1534676-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | Oxford GlycoSciences (UK) Limited (GB) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007453-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058349-A1 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | CERS2, UGCG, GBA1 | ALDH1A1 894/4885TSHR 3068/4885AVPR2 4446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.