Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.49 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018069 | 0.93 | PIK3CD (0.55) | PIK3CDBCL2PDPK1RPS6KB1PIK3CB | |
| SCHEMBL2015977 | 0.85 | PIK3CD (0.66) | PIK3CDBCL2PIK3CBAXLMERTK | |
| SCHEMBL2017994 | 0.85 | PIK3CD (0.55) | PIK3CDBCL2PDPK1RPS6KB1PIK3CB | |
| Trifluoroacetic Acid SCHEMBL2050996 | 0.85 | PIK3CD (0.57) | PIK3CDBCL2PIK3CBAXLMERTK | |
| SCHEMBL2012482 | 0.84 | PIK3CD (0.67) | PIK3CDBCL2PIK3CBAXLMERTK | |
| Trifluoroacetic Acid SCHEMBL2052496 | 0.81 | PIK3CD (0.35) | PIK3CDPDPK1RPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL2164086 | 0.81 | PIK3CD (0.58) | PIK3CDPDPK1RPS6KB1PIK3CBMERTK | |
| SCHEMBL2012816 | 0.81 | PIK3CD (0.59) | PIK3CDBCL2PDPK1RPS6KB1PIK3CB | |
| SCHEMBL2164179 | 0.79 | PIK3CD (0.41) | PIK3CDBCL2PDPK1RPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL9929278 | 0.78 | PIK3CD (0.45) | PIK3CDBCL2PIK3CBAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885BCL2 1174/4885PDPK1 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.