Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2166431 | 0.94 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CAMERTK | |
| SCHEMBL2017399 | 0.92 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CAMERTK | |
| Trifluoroacetic Acid SCHEMBL2165358 | 0.92 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGL3MBTL1PIK3CA | |
| Trifluoroacetic Acid SCHEMBL2164852 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGL3MBTL1PIK3CA | |
| SCHEMBL2016212 | 0.85 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CGPIK3CAMERTK | |
| SCHEMBL2014810 | 0.84 | PIK3CD (0.62) | PIK3CDPIK3CBPIK3CGPIK3CAMERTK | |
| Trifluoroacetic Acid SCHEMBL2163712 | 0.83 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CARPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL2164027 | 0.82 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CGPIK3CAPDPK1 | |
| Trifluoroacetic Acid SCHEMBL2164174 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3CBPDPK1RPS6KB1MERTK | |
| Trifluoroacetic Acid SCHEMBL2163783 | 0.80 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3CGL3MBTL1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885PIK3CB 16/4885PIK3CG 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.