Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21644780 | 1.00 | MAPT (0.62) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL29379020 | 1.00 | MAPT (0.62) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL31727869 | 0.89 | MAPT (0.55) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL10023253 | 0.86 | SOS2 (0.68) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL29405720 | 0.86 | SOS2 (0.68) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL2033277 | 0.86 | SOS2 (0.68) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL31369774 | 0.86 | SOS2 (0.68) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL2033276 | 0.86 | SOS2 (0.68) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL1460650 | 0.86 | MAPT (0.69) | MAPTKMT2ALMNAKDM4EMEN1 | |
| SCHEMBL18029110 | 0.86 | MAPT (0.69) | MAPTKMT2ALMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018057-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | JANSSEN BIOTECH, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-12018057-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | JANSSEN BIOTECH, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-12018057-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | JANSSEN BIOTECH, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| CN-118055773-A | Lipopeptides inhibitors of interleukin-23 receptor | 詹森生物科技公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-113929612-B | Preparation method of etodolac intermediate | 鲁南制药集团股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117999274-A | Peptide inhibitors of interleukin-23 receptor | 詹森生物科技公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117980320-A | Bicyclic peptide inhibitors of interleukin-23 receptor | 詹森生物科技公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-113666860-B | Preparation method of 7-ethyl tryptol | 鲁南制药集团股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| US-11845808-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | JANSSEN BIOTECH, INC. (US) | 2023-12-19 | — | — | US | disclosed |
| US-20220402983-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | JANSSEN BIOTECH, INC. | 2022-12-22 | — | — | US | disclosed |
| CN-115298196-A | Peptide inhibitors of the interleukin-23 receptor and their use for the treatment of inflammatory diseases | 詹森生物科技公司 | 2022-11-04 | — | — | CN | disclosed |
| US-11041000-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | PROTAGONIST THERAPEUTICS, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-20210009638-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2021-01-14 | — | — | US | disclosed |
| US-20200040037-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2020-02-06 | — | — | US | disclosed |
| US-20200040037-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11041000-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
| US-20220402983-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
| US-12018057-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
| US-11845808-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
| US-20200040037-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
| US-20210009638-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | IL23R, IL1RN, VIP | MAPT 2759/4885KMT2A 4527/4885LMNA 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.