⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19869343 | 0.84 | NLRP3 (0.32) | — | |
| SCHEMBL21646764 | 0.81 | NLRP3 (0.30) | — | |
| SCHEMBL25507493 | 0.80 | — | — | |
| SCHEMBL25507986 | 0.73 | — | — | |
| SCHEMBL23691693 | 0.73 | MAPT (0.31) | — | |
| SCHEMBL21646767 | 0.72 | — | — | |
| SCHEMBL25515114 | 0.72 | — | — | |
| SCHEMBL21646560 | 0.71 | — | — | |
| SCHEMBL23674373 | 0.71 | MEN1 (0.31) | — | |
| SCHEMBL23674334 | 0.71 | MEN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253596-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2021-08-19 | — | — | US | disclosed |
| WO-2020018975-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |