Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 16/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18029669 | 0.82 | NLRP3 (0.53) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL25031965 | 0.82 | NLRP3 (0.38) | NLRP3ATMSMN1; SMN2ALDH1A1GSTO1 | |
| SCHEMBL29494713 | 0.81 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| Potassium SCHEMBL29676171 | 0.81 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL25845405 | 0.81 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL22012162 | 0.79 | NLRP3 (0.50) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL28523849 | 0.78 | NLRP3 (0.38) | NLRP3ATMSMN1; SMN2ALDH1A1GSTO1 | |
| SCHEMBL20692050 | 0.73 | BCHE (0.32) | — | |
| SCHEMBL23674551 | 0.73 | BCHE (0.32) | — | |
| SCHEMBL23674508 | 0.73 | BCHE (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020018975-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |