Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | P4HB | P07237 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016174 | 0.92 | PIK3CD (0.54) | PIK3CDDYRK1APIK3CGPIK3R2PIK3CA | |
| Trifluoroacetic Acid SCHEMBL2164086 | 0.87 | PIK3CD (0.58) | PIK3CDPIK3CGRPS6KB1PIK3CAPIK3CB | |
| Trifluoroacetic Acid SCHEMBL2163739 | 0.86 | PIK3CD (0.51) | PIK3CDDYRK1APIK3CGPIK3R2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2166431 | 0.85 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL2165358 | 0.84 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3CAPIK3CBUBE2N | |
| SCHEMBL2017399 | 0.78 | PIK3CD (0.66) | PIK3CDDYRK1APIK3CGPIK3CAPIK3CB | |
| Trifluoroacetic Acid SCHEMBL2163712 | 0.78 | PIK3CD (0.53) | PIK3CDPIK3CGAURKARPS6KB1AURKB | |
| SCHEMBL2011285 | 0.77 | PIK3CD (0.57) | PIK3CDDYRK1APIK3CGPIK3R2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2164027 | 0.77 | PIK3CD (0.43) | PIK3CDPIK3CGAURKARPS6KB1AURKB | |
| SCHEMBL2016212 | 0.77 | PIK3CD (0.77) | PIK3CDPIK3CGPIK3CAPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680108-B2 | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors | INCYTE CORPORATION (US) | 2014-03-25 | — | — | US | disclosed |
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183985-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | PIK3R1, PIK3R3, PIK3R2 | PIK3CD 13/4885ADORA2A 1513/4885ADORA1 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.