Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21633888 | 0.84 | KMT2A (0.60) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL21633889 | 0.84 | KMT2A (0.60) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL18963232 | 0.81 | RRM1 (0.81) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL21649936 | 0.79 | RRM1 (0.66) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL16211059 | 0.77 | KMT2A (0.66) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL14571422 | 0.77 | KMT2A (0.66) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL16211060 | 0.77 | KMT2A (0.66) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL21649940 | 0.77 | RRM1 (0.67) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL18963309 | 0.77 | RRM1 (0.78) | RRM1NPC1KDM4EHTTKMT2A | |
| SCHEMBL18963253 | 0.77 | RRM1 (1.00) | RRM1NPC1KDM4EHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210355103-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE | 2021-11-18 | — | — | US | disclosed |
| WO-2020023802-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | CITY OF HOPE (US) | 2020-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210355103-A1 | PARG INHIBITORS AND METHOD OF USE THEREOF | PARG, PARP12, PARN | RRM1 1674/4885NPC1 1065/4885KDM4E 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.