Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21650529 | 0.89 | HDAC6 (0.48) | HDAC6MAPK14MEN1KMT2AMGAM | |
| SCHEMBL21650531 | 0.88 | ALDH1A1 (0.47) | HDAC6MAPK14GAASMN1; SMN2 | |
| SCHEMBL26485329 | 0.86 | HDAC6 (0.46) | HDAC6MAPK14 | |
| SCHEMBL21634119 | 0.83 | HDAC6 (0.78) | HDAC6 | |
| SCHEMBL21634089 | 0.83 | HDAC6 (0.70) | HDAC6 | |
| SCHEMBL21650586 | 0.82 | TSHR (0.52) | HDAC6MEN1KMT2AGAACACNA2D1 | |
| SCHEMBL21650571 | 0.81 | HDAC6 (0.46) | HDAC6SMN1; SMN2 | |
| SCHEMBL21650530 | 0.81 | HDAC6 (0.51) | HDAC6MAPK14GAASMN1; SMN2 | |
| SCHEMBL21650578 | 0.81 | HDAC6 (0.44) | HDAC6MAPK14SMN1; SMN2 | |
| SCHEMBL21650591 | 0.79 | HDAC6 (0.46) | HDAC6MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3827004-B1 | 4-(1,3,4-OXADIAZOLE-2-YL)PYRIDINE-2(1H)-ONE DERIVATIVES AS HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS FOR THE TREATMENT OF E.G. INFECTIONS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2023-10-11 | — | — | EP | disclosed |
| WO-2020022794-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-01-30 | — | — | WO | disclosed |