Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CHKA | P35790 | 6/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10210891 | 0.85 | MEN1 (0.56) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL6495394 | 0.77 | MAPK1 (0.49) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL14024217 | 0.76 | KDM4E (0.50) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL10212378 | 0.76 | MAPK1 (0.63) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL6483885 | 0.76 | MAPK1 (0.48) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL13559793 | 0.76 | SIGMAR1 (0.65) | MEN1KMT2AKDM4EDRD2DRD4 | |
| SCHEMBL807356 | 0.75 | MAPK1 (0.62) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL3183661 | 0.75 | KDM4E (0.60) | POLBMEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL12316779 | 0.75 | MEN1 (0.85) | POLBMEN1KMT2ACHKAKDM4E | |
| SCHEMBL19869938 | 0.74 | GAA (0.67) | POLBMEN1KMT2AKDM4EDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |