Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653067 | 0.86 | RAF1 (0.47) | LMNARAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL21652891 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL21653088 | 0.81 | MAP3K5 (0.40) | LMNAL3MBTL1KMT2AMAPTTDP1 | |
| SCHEMBL21653155 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL21653182 | 0.79 | KMT2A (0.52) | KDM4ELMNARAB9ASMN1; SMN2KMT2A | |
| SCHEMBL21653272 | 0.79 | SMN1; SMN2 (0.42) | ALDH1A1KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL21652911 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL21652976 | 0.78 | GRM5 (0.51) | ALDH1A1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL21653177 | 0.78 | MAPT (0.46) | ALDH1A1KDM4ERAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL21653267 | 0.78 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |